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Combo-pilling may be the newest fad or also the newest into the future under scrutiny and thus it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there aren't any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure and heartrate, and must not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. 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