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Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which are made up of more than one active ingredient, which might make them more potent and safer. Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that by right now there aren't any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug could also raise blood pressure level and pulse rate, and really should not be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. Approving a drug with this many potentially lethal unwanted side effects is inconsistent while using mission statement of the FDA. The power with the drug manufacturing lobby is blatantly evident inside the approval of countless drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety within the US.
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